Figure 1
(a) An example of the quality of the electron density at the active site allowing unambiguous modelling of the magnesium and water structure. The map was contoured at 1.5σ. (b) The active site of bovine IMPase depicting the octahedral coordination of each magnesium ion (distances in Å). Magnesium ions are depicted in purple and water molecules are depicted in red, light blue, orange and pink according to the revised three-metal mechanism proposed in §3.8. |