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Figure 6
Modelling of the lithium-inhibited IMPase structure based upon that of the yeast Hal2p PAPase–2Mg2+–AMP anion–Li+ complex (Albert et al., 2000BB1), in which the tetrahedral coordination of Li+ at site 2 has been inferred. Replacement of Mg2+-2 by Li+-2 precludes the coordination of W2 and prevents the protonation of the inositolate group after phosphoester hydrolysis, trapping inositolate and Pi in the active site and effectively inhibiting the enzyme.

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
Volume 61| Part 5| April 2005| Pages 545-555
doi:10.1107/S0907444905004038
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