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![[Figure 5]](gx5066fig5mag.jpg)
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Figure 5
Stereo images of the active site of PfPNP–ino and PfPNP–SO4. (a) Inosine-binding pocket of PfPNP. The inosine ligand is in red, while the enzyme is displayed in ribbon representation and coloured by subunit with selected protein side chains coloured in yellow and labelled. Waters are shown in cyan. Enzyme–substrate hydrogen-bonding interactions are shown as dashed lines. The electron density associated with the inosine ligand is an omit map contoured at 0.7σ. (b) Phosphate-binding pocket. The stick model is coloured by subunit with the bound sulfate in orange/red. The 2Fo − Fc electron density contoured at 1.2σ is displayed on the sulfate and surrounding residues. Residues that form salt bridges and hydrogen bonds with the sulfate are labelled. |
![[Figure 5]](gx5066fig5.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
