Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine

Schnick, C.; Robien, M.A.; Brzozowski, A.M.; Dodson, E.J.; Murshudov, G.N.; Anderson, L.; Luft, J.R.; Mehlin, C.; Hol, W.G.J.; Brannigan, J.A.; Wilkinson, A.J.

doi:10.1107/S0907444905020251

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 6
Stereoview of the superposed structures of PfPNP–ino and PfPNP–SO₄. PfPNP–ino (light green) and PfPNP–SO₄ (blue) are displayed as cartoons. The residues that undergo changes in orientation are shown as stick models. Asp206 interacts with Ser91 in PfPNP–ino, while in PfPNP–SO₄ Asp206 is oriented further away from the nucleoside-binding site. Arg88 is hydrogen bonded to sulfate, but is shifted when the sulfate-binding site is empty (as in PfPNP–ino) and interacts with His64 instead.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 61| Part 9| September 2005| Pages 1245-1254

https://doi.org/10.1107/S0907444905020251

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