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Figure 6
Stereoview of the superposed structures of PfPNP–ino and PfPNP–SO4. PfPNP–ino (light green) and PfPNP–SO4 (blue) are displayed as cartoons. The residues that undergo changes in orientation are shown as stick models. Asp206 interacts with Ser91 in PfPNP–ino, while in PfPNP–SO4 Asp206 is oriented further away from the nucleoside-binding site. Arg88 is hydrogen bonded to sulfate, but is shifted when the sulfate-binding site is empty (as in PfPNP–ino) and interacts with His64 instead.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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