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Figure 4
(a) The structure of the inhibitor 5-hydroxylaevulinic acid (labelled OHLA) bound in two conformations to one of the active-site lysines (Lys263) of yeast ALAD. The structure has been refined at 1.9 Å resolution and the corresponding electron density, contoured at 1.0 r.m.s., is shown as purple lines. The active-site zinc ion is shown on the lower right. (b) The same view of the bound inhibitor but showing only one conformation and the resulting positive difference density contoured at 4.5 r.m.s. (shown in magenta) indicating the presence of the other conformer.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 61| Part 9| September 2005| Pages 1222-1226
https://doi.org/10.1107/S0907444905018834
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