Figure 3
Putative B1 subsite and the obstructive C-terminus. Stereoview in which mAng–SO4 (carbon, gold; nitrogen, blue; oxygen, red) is superposed with hAng (PDB code 1b1i
; Leonidas, Shapiro, Allen et al., 1999; grey) and a uridine moiety derived from alignment of mAng–SO4 with the RNase A–uridine vanadate complex (PDB code 1ruv
; Ladner et al., 1997; purple). The side chain of hAng Arg121 is omitted for clarity, while mAng residues beyond the main-chain N atom of Ser120 have no electron density. Dashed lines denote potential hydrogen bonds. |