(a) Relative change in the exposure dose required to achieve a resolution of 1.6 Å as a function of the crystal size and cryoliquid shell volume. The black curve shows variation in the crystal volume. (b) Relative change in the required exposure dose with respect to a crystal with an overall ADP B = 15 Å2 as a function of resolution. (c) Relative change in the required exposure dose for crystals with different mosaicity as a function of resolution. I/σ(I) = 3 in the outer resolution shell was used in all simulations.