journal menu
![[Figure 6]](ol5291fig6mag.jpg)
|
|
Figure 6
Phylogenetic analysis showing relations among selected Kunitz domains. The domains are derived from the two-Kunitz-domain serine protease inhibitors (SPI), which all retain three disulfides, and from the trophoblast Kunitz (TK) domain proteins found in cow and sheep. Proteins from sea anemone and from the egg white of a marine turtle provide outgroups. (a) Alignment of the 22 Kunitz domains with conserved sites shaded. Proteins with a bullet point appended to their names have only two disulfides. (b) Dendrogram showing the consensus tree derived from neighbor-joining, most-parsimonious and maximum-likelihood analyses. Numbers indicate bootstrap percentages from 1000 resampled data sets analyzed by maximum parsimony or, in parentheses, by the neighbor-joining method. Nodes preceding the two-disulfide variants are consistently associated with ancestral three-disulfide proteins at the 95% confidence limit. |
![[Figure 6]](ol5291fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
