Figure 2
Presentation of automated sequence analysis performed using the integrated bioinformatics suite developed at Oxford (OPAL annotation tool and OPTIC database). The schematic shows the SEView-based display for one of the proteins annotated as part of the joint Oxford/York study of proteins from B. anthracis. The target protein sequence runs across the top of the diagram and coloured bars indicate regions of the target sequence that show significant sequence similarity to sequences in bioinformatics/structural databases. The width of each bar is related to the degree of sequence similarity. The different colours indicate different sources of information, e.g. yellow, PDB entries; orange, domain definitions; magenta, SCOP definitions; white, TargetDB entries. Clicking on any bar will bring up further information. The example indicated by the red arrow shows the detailed comparison of the target sequence to a COG family. |