Figure 6
Coverage achieved by various commercial screens and by two `virtual' screens in crystallizing proteins of different origins at the Oxford node. The coverage shown represents the percentage of proteins crystallized with each screen when compared with the total number of proteins crystallized for each group. The number of proteins crystallized for each protein origin is given in parentheses and above each column. The commercially available screens each contained 48 different conditions. Based on the conditions of these actual screens, `virtual screens' can be constructed. A virtual JCSG+ screen comprising 86 of the 96 conditions would give good coverage of proteins with bacterial and virus origins, but a much reduced coverage for eukaryotic proteins. (Details of the JCSG+ screen are given in the text). Preliminary analysis of the data indicates that the `Virtual Best Screen' of 96 conditions would cover more than 90% of all the proteins crystallized, irrespective of their origin. |