Figure 3
Ribbon diagram representation of the apo-ZAP70 SH2 domains and inter-SH2 domain linker (based on Folmer et al., 2002). The N-terminal SH2 domain is shown in green and the C-terminal SH2 domain is shown in red. These SH2 domains have to come together to form the binding site for the ITAM bisphosphorylated peptide (see Hatada et al., 1995). |