Figure 2
(a) Ribbon diagram showing the binding of imatinib (green C atoms) to Abl kinase (helices in red, strands in blue, loops and turns in grey), with the locations of mutants isolated from imatinib-resistant patients shown in yellow. (b) Details of the binding of imatinib (green C atoms) to Abl kinase (gray C atoms) showing potential hydrogen bonds as orange dotted lines. |