 | Acta Crystallographica Section D Acta Crystallographica Section D BIOLOGICAL CRYSTALLOGRAPHY |
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![[Figure 4]](ba5102fig4mag.jpg)
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Figure 4
(a) Superposition of the four main DFG conformations observed in Abl kinase structures, with the active conformation in cyan, the DFG-out conformation in yellow, the DFG-flip conformation in grey and the Src-like inactive conformation in green. (b) Superposition of all structures reported here plus PDB entry 2g1t . The P-loop is shown in red, the C-helix is cyan, the A-loop is blue and all the ligands are shown in green. The superposition is based on an alignment of the C-terminal lobes to emphasize the relative differences in angles between the N- and C-terminal lobes of the kinase. (c) A stereoview of all the ligands superimposed (imatinib, magenta C atoms; NVP-AFN941, cyan C atoms; NVP-AFG210, yellow C atoms; NVP-AEG082, green C atoms; PD180970, grey C atoms). |
![[Figure 4]](ba5102fig4.jpg)
| BIOLOGICAL CRYSTALLOGRAPHY |
ISSN: 1399-0047
