Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia

Cowan-Jacob, S.W.; Fendrich, G.; Floersheimer, A.; Furet, P.; Liebetanz, J.; Rummel, G.; Rheinberger, P.; Centeleghe, M.; Fabbro, D.; Manley, P.W.

doi:10.1107/S0907444906047287

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 7
Superposition of the structures of imatinib (magenta) and nilotinib (green) as bound to Abl kinase (cyan and grey, respectively). Potential hydrogen bonds are shown as dotted red lines for the imatinib complex and dotted grey lines for the nilotinib complex.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 63| Part 1| December 2007| Pages 80-93

doi:10.1107/S0907444906047287

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