Figure 5
Overlay of the crystal structures of the Src SH2 domain with acetylated pYEEI peptide (PDB code 1a1b
; in yellow) and the urazole derivative of the YEEI peptide (in green; Chung et al., in preparation). The extensive hydrogen-bonding interactions made by the urazole are shown by dotted green lines. The excellent phosphate mimicry of the urazole heterocycle within this recognition pocket is evident. |