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![[Figure 4]](en5210fig4mag.jpg)
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Figure 4
2Fobs − 1Fcalc electron-density maps for (a) PfENR and (b) TgENR contoured at 0.8σ produced after initial rigid-body refinement in REFMAC5 (Murshudov et al., 1997  ). Both NAD+ and triclosan were omitted from the model during refinement, but are represented in stick format in order to show their unambiguous position in the initial electron-density maps. (c) Stereo diagram of the residues responsible for forming a hydrogen-bonding network to the NAD+ cofactor in subunit A of TgENR. (d) Stereo diagram of the triclosan-binding site of subunit A of TgENR, with the active-site residues Tyr179, Tyr189, Lys197 and Phe243 labelled. (c) and (d) use the colour scheme yellow, red, blue, green and orange for carbon, oxygen, nitrogen, chlorine and phosphorus, respectively, and were produced in TURBO-FRODO (Roussel et al., 1990). |
![[Figure 4]](en5210fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
