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Figure 1
Phase diagram illustrating the control process for crystal growth in the metastable zone in the case of a protein with direct solubility. The solubility curve (red points) as well as the sequence representing the various steps (blue arrows) of the actual crystal-growth process of hydrogenated recombinant urate oxidase complexed with 8-azaxanthin in the presence of D2O is schematized. The photographs show the crystal habits and volume of a seeded crystal observed before equilibration at 298, 293, 288, 283 and 278 K, respectively.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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