 | Acta Crystallographica Section D Acta Crystallographica Section D BIOLOGICAL CRYSTALLOGRAPHY |
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![[Figure 1]](dz5135fig1mag.jpg)
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Figure 1
Structure of the CH2 antibody domain and structural comparison with the corresponding region in the Fc and IgG structures. (a) Ribbon diagram of the isolated unglycosylated CH2 domain from IgG γ1 is shown with a gradient ramp of colors according to the temperature factors (B factors): blue for lower (∼11 Å2), green for medium (∼23 Å2) and red for higher (∼48 Å2) values. The N- and C-termini as well as strands A–G are marked. (b) The isolated CH2 domain (green) was superimposed with a least-squares algorithm using the Cα traces of the CH2 domains of fucosylated (blue; PDB code 2dtq ) and nonfucosylated (purple; PDB code 2dts ) Fc structures. (c) Superposition of the isolated CH2 structure (green) with that of CH2 portions of an intact IgG (PDB code 1hzh ) using the Cα-trace alignment. The heavy and light chains of IgG are shown in red and blue, respectively. The carbohydrate moieties between the CH2 domains of the Fc and IgG structures in (b) and (c) are omitted for clarity. |
![[Figure 1]](dz5135fig1.jpg)
| BIOLOGICAL CRYSTALLOGRAPHY |
ISSN: 1399-0047
