Figure 2
Structural details of the Pol II elongation complex. (a) Overview of the EC structure (Kettenberger et al., 2004 ). The view is as in Fig. 1 (a). (b) Superposition of NTP-binding sites [red, insertion site (Westover et al., 2004a ; Wang et al., 2006 ); violet, entry site (Westover et al., 2004a ); pink, inactive pre-insertion-like state in which the triphosphate is too far from the catalytic metal ion A to allow incorporation (Kettenberger et al., 2004 )]. (c) Functional Pol II surface elements in the EC highlighted in yellow. This figure was adapted from Cramer et al. (2008 ). |