 | Acta Crystallographica Section D Acta Crystallographica Section D BIOLOGICAL CRYSTALLOGRAPHY |
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![[Figure 5]](mh5021fig5mag.jpg)
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Figure 5
Summary of the development of the present TIPP compounds from a PPARα-specific agonist, KCL. The TIPP agonists used in this study were all developed from KCL using structure–activity relation (SAR) studies. When specific chemical groups, coloured magenta, were introduced into the ligand compounds, the transactivation abilities were drastically changed. The modification effects of the agonist ligands were found to increase the protein–ligand interactions at specific positions in the ligand-binding pockets. |
![[Figure 5]](mh5021fig5.jpg)
| BIOLOGICAL CRYSTALLOGRAPHY |
ISSN: 1399-0047
