issue contents

Journal logoBIOLOGICAL
ISSN: 1399-0047

January 2010 issue

Highlighted illustration

Cover illustration: Pseudo-hexagonal packing arrangement of a collagen model peptide (Pro-Pro-Gly)4-Hyp-Hyp-Gly-(Pro-Pro-Gly)4 (ppg9-OOG_H). The asymmetric unit consists of ABC and DEF molecules (marked by green filled circles). Molecules shown as stick models are directed upwards from the paper, whereas those shown as ball-and-stick models are directed downwards from the paper (p. 88).


Acta Cryst. (2010). D66, 1
doi: 10.1107/S0907444909054481

research papers

Acta Cryst. (2010). D66, 2-11
doi: 10.1107/S0907444909037731
link to html
Structure determination was successfully carried out using single Laue exposures from a group of lysozyme crystals. The Laue method may be a viable option for collection of one-shot-per-crystal data from microcrystals.

Acta Cryst. (2010). D66, 12-21
doi: 10.1107/S0907444909042073
link to html
MolProbity structure validation will diagnose most local errors in macromolecular crystal structures and help to guide their correction.

Acta Cryst. (2010). D66, 22-25
doi: 10.1107/S0907444909042589
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The molecular-replacement program MOLREP is described.

Acta Cryst. (2010). D66, 26-32
doi: 10.1107/S0907444909042838
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The distribution of the twinning ratio of crystals of bacteriorhodopsin was studied under a variety of in meso crystallization conditions. A condition favouring the growth of untwinned crystals was determined.

Acta Cryst. (2010). D66, 33-43
doi: 10.1107/S0907444909043030

Acta Cryst. (2010). D66, 44-50
doi: 10.1107/S0907444909043972
link to html
Monitoring changes in B values using self-interaction chromatography combined with crystallization trials resulted in single straight-edged crystals of light-harvesting complex 1–reaction centre from A. vinosum. The method allows the rapid screening of additives and detergents.

Acta Cryst. (2010). D66, 51-60
doi: 10.1107/S0907444909044175
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The X-ray structure (at 1.86 Å resolution) of S. typhimurium uridine nucleoside phosphorylase complexed with its inhibitor 2,2′-anhydrouridine and phosphate and potassium ions is reported.

Acta Cryst. (2010). D66, 61-72
doi: 10.1107/S0907444909043960
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The structure of dihydrodipicolinate reductase from M. tuberculosis has been determined in three different crystal forms as the apo form of the enzyme and as a binary complex with the cofactor NADH. A comparison of the structures reveals a striking domain rotation, which can be rationalized by normal-mode analysis.

Acta Cryst. (2010). D66, 73-79
doi: 10.1107/S0907444909045715
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The low molecular weight PNP from Schistosoma mansoni is shown to bind adenosine in a similar fashion to that observed for the 6-oxo purine substrates. This important difference with respect to the human enzyme, which is unable to bind adenosine, is explained on the basis of minor details to the active site and the corresponding water structure.

Acta Cryst. (2010). D66, 80-87
doi: 10.1107/S0907444909046411
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The crystal structure of MK2 bound to TEI-I01800, a pyrazolo[1,5-a]pyrimidine-scaffold inhibitor, showed an α-helical Gly-rich loop. The secondary structure of the Gly-rich loop might be regulated by the ligand structure.

Acta Cryst. (2010). D66, 88-96
doi: 10.1107/S0907444909046642
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Two crystal modifications of a collagen model peptide with a Hyp-Hyp-Gly sequence in the middle of 27 residues were analyzed at high resolution. Differences between the molecular interactions of these modifications revealed clear preferences for the Hyp(X) puckering.

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A toolkit for the characterization of CCD cameras has been developed. Its use has been demonstrated by the characterization of three in-house transmission electron microscopy detectors, yielding statistics such as the number of outliers, the modulation transfer function, the conversion factor, the effective gain and the detective quantum efficiency.

international union of crystallography

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