Adenosine binding to low-molecular-weight purine nucleoside phosphorylase: the structural basis for recognition based on its complex with the enzyme from Schistosoma mansoni

Pereira, H.M.; Rezende, M.M.; Castilho, M.S.; Oliva, G.; Garratt, R.C.

doi:10.1107/S0907444909045715

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 5
The importance of w309 in the adenosine complex and its analogue (w394) in the crystal structure of the complex of Cellulomonas sp. PNP with 8-aminoguanine. The presence of this water in the bovine and human enzymes is sterically prohibited by the side chain of Val245. (a) Cellulomonas sp. PNP bound to 8-aminoguanine, (b) bovine PNP bound to inosine and (c) S. mansoni PNP bound to adenosine.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 66| Part 1| December 2010| Pages 73-79

doi:10.1107/S0907444909045715

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