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Figure 4
The NADP-binding site in the ASADH enzyme family. (a) NADP bound in caASADH and the residues involved in the cofactor-binding domain. A 2Fo − Fc OMIT map of this region contoured at 1σ shows good electron density for the AMP portion of the NADP cofactor but little density for the NMN portion. (b) Comparison of the conformations of NADP bound in the ASADH structures from C. albicans (green), S. pneumonia (red) and V. cholerae (blue). |