 | Acta Crystallographica Section D Acta Crystallographica Section D BIOLOGICAL CRYSTALLOGRAPHY |
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![[Figure 8]](xb5018fig8mag.jpg)
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Figure 8
Polar interactions in the complex of 5 with the Grb2 SH2 domain. All labile H atoms have been omitted for clarity except those on protein backbone N atoms. Only those ordered water molecules that mediate a single protein–ligand interaction are shown and these are numbered so that water molecules that are conserved in at least two complexes have the same number. Solid lines in (a) and (b) indicate those polar contacts that are conserved for all complexes. (a) Interactions between the domain and the Ac-pY replacement. (b) Interactions between the domain and the X–N region of the ligand. |
![[Figure 8]](xb5018fig8.jpg)
| BIOLOGICAL CRYSTALLOGRAPHY |
ISSN: 1399-0047
