Figure 6
Comparison of FOXO4-DBD with previously reported structures of FOXO-DBD. For clarity, only the DNA in the FOXO4-DBD–DNA complex is shown. (a) Superimposition of the FOXO4-DBD–DNA structure (shown in orange) with the solution structure of apo FOXO4-DBD (shown in blue; Weigelt et al., 2001). (b) Superimposition of the FOXO4-DBD–DNA complex (orange) with the crystal structures of the FOXO3-DBD–DNA (violet; Tsai et al., 2007) and FOXO1-DBD–DNA (magenta; Brent et al., 2008) complexes. |