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Figure 2
Two types of contacts commonly found in crystals obtained by SER engineering. (a) A homotypic symmetric contact creating a crystallo­graphic dimer in the RGSL domain of PDZ-RhoGEF (PDB entry 1htj ; Longenecker et al., 2001BB23). Alanines replacing Lys463, Glu465 and Glu466 are shown as magenta spheres. The twofold axis is perpendicular to the plane of the drawing. (b) Heterotypic contacts (arrows) that mediate interactions between noncrystallographic dimers of a putative NTP pyrophosphorylase (PDB entry 3n77 ). The dimer interface is mediated by a wild-type surface.

Journal logoBIOLOGICAL
ISSN: 1399-0047
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