Figure 4
Stereoview of the positioning of important residues in the substrate-binding pockets and the DNA-interacting parts of DrAlkA2 (grey) and EcAlkA in complex with DNA (PDB entry 1diz
, pink): the catalytic residues (Asp177 and Asp238), the suggested base-stacking residues (Trp212 and Trp272), the DNA-intercalating residues (Gln73 and Leu125), Tyr239 and Leu178 which are located at the entrance of the DNA-binding cleft and the DNA-interacting residues (Arg107 and Lys170). |