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![[Figure 3]](yt5043fig3mag.jpg)
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Figure 3
Overall structure of the ADP–Eg5–ispinesib ternary complex (chain B). (a) Front view of the Eg5 motor domain in complex with Mg2+ (red), ADP (blue) and ispinesib (magenta); red dotted lines indicate the locations of the disordered loops L10 and L11, and selected secondary-structure elements and loops are labelled. (b) Back view of the Eg5 motor domain with α4 of the switch II cluster, the neck-linker region as well as the preceding α6 helix highlighted in magenta. (c) Detailed view of helices α4 and α6 as well as the neck-linker region of the Eg5–ispinesib complex (magenta) superimposed on the apo Eg5 structure (blue; PDB entry 1ii6; Turner et al., 2001  ). |
![[Figure 3]](yt5043fig3.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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