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![[Figure 4]](yt5043fig4mag.jpg)
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Figure 4
Interactions of ispinesib with the Eg5 inhibitor-binding region and comparison with other inhibitors of Eg5. (a) Chemical structure of ispinesib (left); stereoview of ispinesib (purple sticks) bound to the allosteric site of Eg5. Side chains and/or backbone atoms of interacting protein residues are shown as grey sticks and labelled; the protein surface is displayed semitransparently. Unbiased (i.e. calculated prior to including the ligand in the model) σA-weighted Fo − Fc electron density for the ligand contoured at 2.5σ is shown in slate. (b) Chemical structure (left) and comparison of the Eg5 binding mode (right) of `compound 24' (orange). (c) Chemical structure (left) and comparison of the Eg5 binding mode (right) of MK-0731 (orange). |
![[Figure 4]](yt5043fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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