|
Figure 2
(a) Structure of the HuR RRM1/2–RNA complex. All of the RNA bases are labelled. (b) The RNA element is located in a positively charged cavity formed by HuR RRM1 and RRM2. Positive charges and negative charges are coloured blue and red, respectively. (c) View of the RNA element covered with a 2Fo − Fc electron-density map contoured at 1σ. The RNA element is shown in ball-and-stick representation. (d) Superposition of RRM1 from the RNA-free and RNA-bound forms of HuR RRM1/2. The RRM1 and RRM2 domains and the RNA element are coloured red, yellow and cyan, respectively. |