Structural basis for the inhibition of Mycobacterium tuberculosis l,d-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

Kim, H.S.; Kim, J.; Im, H.N.; Yoon, J.Y.; An, D.R.; Yoon, H.J.; Kim, J.Y.; Min, H.K.; Kim, S.-J.; Lee, J.Y.; Han, B.W.; Suh, S.W.

doi:10.1107/S0907444912048998

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 1
Overall structure of Ldt_Mt2Δ130. (a) Ribbon diagram of meropenem-complexed Ldt_Mt2Δ130. The NTD and the Ldt domain are shown in green and yellow, respectively. The active-site lid (His300–Asp323) and the C-terminal tail (Asn379–Ala408) are coloured red and blue, respectively. Meropenem bound to the Ldt domain is shown as a stick model. (b) Domains of Mtb Ldt_Mt2 coloured as in (a). TM, transmembrane helix. (c) Topology diagram of Ldt_Mt2Δ130 coloured as in (a). (d) Electrostatic surface diagram of meropenem-complexed Ldt_Mt2Δ130. Blue and red indicate positive and negative electrostatic potentials at neutral pH, respectively.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 69| Part 3| February 2013| Pages 420-431

doi:10.1107/S0907444912048998

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