Structural basis for the inhibition of Mycobacterium tuberculosis l,d-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

Kim, H.S.; Kim, J.; Im, H.N.; Yoon, J.Y.; An, D.R.; Yoon, H.J.; Kim, J.Y.; Min, H.K.; Kim, S.-J.; Lee, J.Y.; Han, B.W.; Suh, S.W.

doi:10.1107/S0907444912048998

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 2
Structural comparisons and domain interactions in Ldt_Mt2Δ130. (a) A superposition of the four chains in the three Ldt_Mt2Δ130 models and a plot of the C^α r.m.s. deviations between any pair of chains averaged over the six pairwise comparisons. The apo, mercury-derivatized and meropenem-complexed Ldt_Mt2 (chains A and B) are coloured orange, magenta, yellow and blue, respectively. (b) Interactions between the C-terminal tail and two domains coloured as in Fig. 1

(a). The enlarged views on the left have slightly different orientations in order to show the detailed interactions better.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 69| Part 3| February 2013| Pages 420-431

doi:10.1107/S0907444912048998

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