Structural basis for the inhibition of Mycobacterium tuberculosis l,d-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

Kim, H.S.; Kim, J.; Im, H.N.; Yoon, J.Y.; An, D.R.; Yoon, H.J.; Kim, J.Y.; Min, H.K.; Kim, S.-J.; Lee, J.Y.; Han, B.W.; Suh, S.W.

doi:10.1107/S0907444912048998

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

IUCr IT WDC

home archive editors for authors for readers submit subscribe open access

view article

Figure 3
Big_5 domain of Ldt_c_Mt2. (a) Topology diagrams of the Big_5 domain (His150–Gly250) of Ldt_Mt2Δ130 (inset) and of four distinct subtypes of the Ig-like fold (modified from Bork et al., 1994

): c-type (constant), v-type (variable), s-type (switched) and h-type (hybrid). The four-stranded structural core (strands b, c, e, and f; β2, β3, β5 and β6 of Ldt_Mt2Δ130) common to all Ig-like domains (orange) is surrounded by structurally more variable strands (green). (b, c) Ribbon diagrams of the Big_5 domain (His150–Gly250) in the apo model of Ldt_Mt2Δ130 (b) and meropenem-complexed Ldt_Mt2Δ130 (c), and enlarged views of the β6–β7 loop (insets) coloured as in (a). The bound calcium ion and the residues around it (Asp232–Met237) are shown as a purple ball and as stick models, respectively, with a 2mF_o − DF electron-density map (contoured at 1.5σ).

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 69| Part 3| February 2013| Pages 420-431

doi:10.1107/S0907444912048998

Follow Acta Cryst. D

Search IUCr Journals		doi		Advanced search
Author		volume	page