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Figure 2
Dimeric structure of the R298A mutant of SARS-CoV Mpro. (a) The overall structure of the dimeric Mpro R298A mutant. The two protomers are coloured cyan and green, respectively. (b) Crystal packing of the R298A mutant. Two molecules form a biological dimer in the unit cell. (c) Final 2Fo − Fc electron density contoured at 1.0σ for residues 297–299 of the R298A mutant. The Arg298 residue in wild-type Mpro is also shown (grey). (d) Schematic drawing in stereoview showing the detailed interactions at the active site of the R298A mutant. The residual electron density around the active site is contoured at 2.5σ (green mesh) and the C atoms of the modelled P3–P1 (Val-Leu-Gln) residues are coloured orange. Hydrogen-bonding interactions are indicated by red dashed lines. All structure figures were produced with PyMOL (http://www.pymol.org ).

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
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