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Figure 2
The scales of structural biology and their relationship to the currently available archives (EMDB and PDB): from the atomic details and interactions in a binding site to the cellular context of molecular machines, illustrated using the ribosome as an example. From left to right: soft X-ray tomogram of a fission yeast cell (adapted from Larabell & Nugent, 2010BB58 with permission of Elsevier), electron tomogram of ribosomes in the cytosol (EMDB entry EMD-5227; Brandt et al., 2010BB20), cryo-EM reconstruction of the 80S ribosome from yeast (EMDB entry EMD-2008; Becker et al., 2012BB9), crystal structure of the 50S ribosomal subunit (PDB entry 3uzk ; Demeshkina et al., 2012BB32) and crystal structure revealing how tmRNA and the small protein SmpB enable the kirromycin-stalled 70S ribosome to proceed with translation (PDB entries 4abr and 4abs ; Neubauer et al., 2012BB66).

Journal logoBIOLOGICAL
ISSN: 1399-0047
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