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Figure 2
Primary-sequence alignment and superposition of CobDH and homologous proteins for which crystal structures have been solved. (a) Multiple sequence alignment of all deposited proteins that bind methylcobalamin in the base-off/His-on form. The histidine side chain from the conserved cobalamin-binding motif DxHxxG forms a coordination bond with the central Co atom in all cases. Conserved residues of CobDH (Asp100, His102 and Ser147) are marked with asterisks. The alignment was performed using ClustalX (Larkin et al., 2007 ![]() ![]() ![]() |