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Figure 4
Details of the final steps of phenazine biosynthesis. Uncatalysed reactions leading to less reactive intermediates are shown in light grey. The second dehydration step in the PhzA/B-catalysed condensation of two AOCHC molecules generates the central HHPDC isomer 1, which can then immediately be oxidized by PhzG or undergo oxidative decarboxylation, leading to PDC, PCA or phenazine via the indicated routes. DHPDC and DHPCA (highlighted in green) are the final products of the pathway and act as precursors for strain-specific phenazine derivatives.

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
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