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Figure 1
Outline of the clavulanic acid biosynthesis pathway in S. clavuligerus, showing identified intermediates and the enzymes involved. The proposed branch-point intermediate clavaminic acid is shown in blue and CA is shown in red [CEAS (ORF2), carboxyethyl arginine synthase; β-LS (ORF3), β-lactam synthase; CAS (ORF5), clavaminate synthase; PAH (ORF4), proclavaminate synthase; OAT2 (ORF6), ornithine acetyltransferase; CAD (ORF9), clavulanate dehydrogenase; Kershaw et al., 2005 ![]() |