Figure 8
Preserved packing interactions across mycobacterial NATs. The blue surface represents a conserved proposed dimerization interface (I: molecules a and c) observed in all mycobacterial NAT structures determined thus far, as well as in those from S. typhimurium, N. farcinica and P. aeruginosa, whilst the red surface highlights another intermolecular interface (II) that is conserved only within known mycobacterial structures. (a) TBNAT. (b) MMNAT. (c) Cα traces of the superimposed TBNAT (pink) and MMNAT (grey) structures demonstrate substantial overlap in crystal packing involving the preserved interfaces despite the fact that they crystallize in different space groups. |