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![[Figure 2]](dz5287fig2mag.jpg)
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Figure 2
T. maritima IMPCT crystal structure. (a) Ribbon representation in which the color changes from blue at the N-terminus to red at the C-terminus. The arsenoribose (As-rib) in the active site is marked in magenta, the residues suggested to aid in membrane binding are shown in red, the disulfide is shown in yellow, the solute molecules are shown in blue and the seven β-strands are numbered. (b) Structural comparison of the structure of IMPCT from T. maritima (gray) with nine representative sugar nucleotidyltransferases: PDB entries 1fxo (green; Pseudomonas aeruginosa glucose-1-phosphate thymidylyltransferase; Blankenfeldt et al., 2000  ), 1h5r (light yellow; E. coli glucose-1-phosphate thymidylyltransferase; Zuccotti et al., 2001), 1lvw (light gray; Methanothermobacter thermautotrophicus glucose-1-phosphate thymidylyltransferase; Northeast Structural Genomics Consortium, unpublished work), 1vpa (orange; T. maritima 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Joint Center for Structural Genomics, unpublished work), 1tzf (pink; S. enterica glucose-1-phosphate cytidylyltransferase; Koropatkin & Holden, 2004), 2pa4 (light green; Corynebacterium glutamicum glucose-1-phosphate uridylyltransferase; Thoden & Holden, 2007), 2qkx (magenta; M. tuberculosis N-acetyl glucosamine 1-phosphate uridyltransferase; Zhang et al., 2009), 2xme (blue; Archaeoglobus fulgidus inositol-1-phosphate cytidylyltransferase; Brito et al., 2011) and 4evw (yellow; Vibrio cholerae nucleoside-diphosphate-sugar pyrophosphorylase; Northeast Structural Genomics Consortium, unpublished work). |
![[Figure 2]](dz5287fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
