Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

Krintel, C.; Harpsøe, K.; Zachariassen, L.G.; Peters, D.; Frydenvang, K.; Pickering, D.S.; Gajhede, M.; Kastrup, J.S.

doi:10.1107/S0907444913011839

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 3
CX516 (yellow stick representation) binds at the dimer interface of GluA2 LBD-L483Y-N754S in two different orientations and (S)-glutamate (blue stick representation) binds at the agonist-binding site. The protein molecules are shown as salmon (molecule A) and cyan (molecule B) cartoon representations.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 69| Part 9| September 2013| Pages 1645-1652

https://doi.org/10.1107/S0907444913011839

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