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![[Figure 1]](mh5092fig1mag.jpg)
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Figure 1
Overlay of the XIAP BIR2 crystal structure at 1.35 Å resolution (orange), the NMR structure (green; PDB entry 1c9q; Sun et al., 1999  ) and the caspase-3-bound form (light blue; PDB entry 1i3o; Riedl et al., 2001). The construct used in crystallization removes the flexible and variable preceding linker region as well as residues from the C-terminus. For the apo structure, only chain A is shown; in the other molecule the N-terminus is disordered up to residue 159. The zinc is shown as a sphere and Trp210, which creates the floor of the binding groove, is shown in stick representation. |
![[Figure 1]](mh5092fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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