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Figure 3
(a) Overlay of ATAA (green), SVPI (orange) and AIAV (blue). A combination of peptide movement and rotation of Gln197 allows the protein to accommodate the differently sized P4 residues. Gln197 was observed in two conformations in the SVPI structure. (b) Overlay of SVPI (orange) and AVPI (red). Instead of Gln197 moving away, the peptide is pushed out. (c) Overlay of SVPI (orange) and AMRV (blue). The arginine causes the backbone to shift enough that the hydrogen bond to the Leu207 backbone is lost.

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ISSN: 2059-7983
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