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Figure 4
(a) Overlay of AVPI structures: XIAP BIR2–SVPI in orange, XIAP BIR3–AVPI in cyan (PDB entry 1g73; Wu et al., 2000BB39), MLIAP–AVPI in turquoise (PDB entry 1oxq; Franklin et al., 2003BB10) and CIAP1 BIR3–AVPI in dark blue (PDB entry 3d9u; Kulathila et al., 2009BB18). Note that Lys206 is a glycine in XIAP BIR3, MLIAP and CIAP BIR3 and this restricts the size of the pocket, so that P4 is buried less deeply. (b) Overlay of XIAP BIR2 with AIAV bound (green) and DIAP1 BIR1 with the Grim peptide bound (purple; AIAY from Grim shown; PDB entry 1seo). In this case, Lys208 is a glycine in DIAP1 BIR1, allowing the large tyrosine at P4 to fit.

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