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Figure 2
Fusion proteins and chaperones in GPCR crystallography. Extensive use of antibody fragments and fusion proteins has facilitated GPCR structure determination and molecular-replacement phasing. Shown here are structures of β2AR solved with the aid of a Fab fragment, T4 lysozyme fusion protein and a camelid nanobody. In each case, the percentage of the final model comprised by the crystallization chaperone is indicated.

Journal logoBIOLOGICAL
ISSN: 1399-0047
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