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Figure 5
Surface representation of the final refined structure of the yeast exosome complex with the bound RNA in black (PDB entry 4ifd ; Makino, Baumgärtner et al., 2013BB17). 5′ duplex RNA interacts with the cap proteins Rrp4 (orange) and Rrp40 (beige), and is in close proximity to Csl4 (yellow). The 3′ single-stranded extension passes through a central channel formed by RNase PH subunits, shown in different shades of grey. This RNA path extends into the exoribonuclease Rrp44 (violet), which is found in a closed conformation. A magnesium ion, shown as a red sphere, is found at the Rrp44 active site.

Journal logoBIOLOGICAL
ISSN: 1399-0047
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