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Figure 1
(a) An overview of the approach used by MR-Rosetta to refine models against noisy density data resulting from difficult molecular-replacement problems. In addition to identifying the correct solution from among a list of candidates, MR-Rosetta is often able to improve the model enough so that automatic chain tracing can solve (or very nearly solve) the structure. (b) How Rosetta combines sequence information to guide backbone sampling with energetics and experimental data during refinement.

Journal logoBIOLOGICAL
ISSN: 1399-0047
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