Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights

Róna, G.; Marfori, M.; Borsos, M.; Scheer, I.; Takács, E.; Tóth, J.; Babos, F.; Magyar, A.; Erdei, A.; Bozóky, Z.; Buday, L.; Kobe, B.; Vértessy, B.G.

doi:10.1107/S0907444913023354

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 2
Phosphorylation-dependent cellular localization patterns of dUTPase. 293T cells transiently expressing DsRed-fused WT, S11E and S11Q dUTPases were visualized. The WT construct and the S11Q (hypophosphorylation-mimicking) mutant are mainly nuclear, while the S11E (hyperphosphorylation-mimicking) mutant is clearly excluded from the cell nucleus. The scale bar represents 20 µm.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 69| Part 12| December 2013| Pages 2495-2505

https://doi.org/10.1107/S0907444913023354

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