journal menu
![[Figure 5]](dw5072fig5mag.jpg)
|
|
Figure 5
Crystal structure of MBPA216H_K220H-SUFU-ΔW61D_L62S_G63F_P453A_Δ454–456_K457A in complex with GLI3p. (a) Superposition of the N-terminal domains of apo (yellow with grey linker) and peptide-bound (beige, N-terminal domain; green, C-terminal domain; purple linker) structures shows a 58° rotation of the C-terminal domain via a flexible linker. (b) The position of GLI3p in the MBP-216H_220H_-SUFU-ΔW61D_L62S_G63F_P453A_Δ454–456_K457A–peptide co-crystal. An averaged kick OMIT map contoured at 3.0σ shows well defined density for GLI3p lying between the β-sheets of the SUFU N-terminal domain (beige) and C-terminal domain (green). |
![[Figure 5]](dw5072fig5.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
Open 
access
access
