Figure 3
The overall structure of HpyMqnB (a) shows both an open form (ice blue) and a ligand-bound form (gold) dimerized through two α-helices and a loop. The interacting loop could have an allosteric effect as its residues are close to the active site, which contains an adenine and a Tris molecule which interact by a hydrogen-bonding network (b). Figures were produced using CCP4MG (McNicholas et al., 2011). |